Publications

If you are interested in the science behind this wonderful therapy the following is a list of some of the published research papers using LLLT or Photobiomodulation in clinical settings for treatment and the amazing results. This area is constant and ongoing so this is by no means a comprehensive list.

DENTAL

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Ana Paula Silveira Turrioni, Liege Aldrovandi Montoro, Fernanda Gonçalves Basso, Leopoldina de Fátima Dantas de Almeida, Carlos Alberto de Souza Costa, Josimeri Hebling. "Dose-responses of Stem Cells from Human Exfoliated Teeth to Infrared LED Irradiation ."  Brazilian Dental Journal (2015) 26(4): 409-415. http://dx.doi.org/10.1590/0103-6440201300148 .  ISSN 0103-6440.

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Mohammed Abdul Hadis; Patricia Gorecki and William M Palin; "Biomodulatory effects of laser irradiation on dental pulp cells in vitro." ResearchGate Conference Paper · February 2015 DOI: 10.1117/12.2077717 https://www.researchgate.net/publication/278673753.

STIMULATE STEM CELLS / CELL HEALTH

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Ayad G. Anwer, PhD, Martin E. Gosnell, PhD, Sandeep M. Perinchery, PhD, David W. Inglis, PhD, and Ewa M. Goldys, PhD. "Visible 532 nm Laser Irradiation of Human Adipose Tissue-Derived Stem Cells: Effect on Proliferation Rates, Mitochondria Membrane Potential and Autofluorescence." Accepted 14 September 2012 Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/lsm.22083

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Kirlin WG, Cai J, Thompson SA, Diaz D, Kavanagh TJ & Jones DP. (1999). "Glutathione redox potential in response to differentiation and enzyme inducers". Free Radic Biol Med, 27, 1208-18.

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Leopoldina de F D de Almeida ; Ana Paula Turrioni ; and Fernanda Basso. "Red LED Photobiomodulates the Metabolic Activity of Odontoblast-Like Cells." Brazilian dental journal · August 2016. DOI: 10.1590/0103-6440201600152. https://www.researchgate.net/publication/308278961.

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Pastore D, Greco M, Petragallo VA & Passarella S. (1994). "Increase in H+/e- ratio of the cytochrome c oxidase reaction in mitochondria irradiated with helium-neon laser". Biochem Mol Biol Int, 34, 817-26. 

NAD+ as the Link Between Oxidative Stress,
Inflammation, Caloric Restriction, Exercise,
DNA Repair, Longevity, and Health Span

Praveen R. Arany, DDS, PhD. "Photobiomodulation Therapy: Communicating with Stem Cells for Regeneration?". Photomedicine and Laser Surgery, Volume 34, Number 11, 2016, Mary Ann Liebert, Inc., Pp. 497–499. DOI: 10.1089/pho.2016.4203.

Scott C Kelsey. Graduate Assistant; Department of Biomedical Sciences; Missouri State University Kelsey6@live.missouristate.edu.  "Qualification and Quantification of Telomeric Elongation Due to Electromagnetic Resonance Exposure."

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Turrens JF. (2003). "Mitochondrial formation of reactive oxygen species". J Physiol, 552, 335-44. 

Yang M, Nazhat NB, Jiang X, Kelsey SM, Blake DR, Newland AC & Morris CJ. (1996). "Adriamycin stimulates proliferation of human lymphoblastic leukaemic cells via a mechanism of hydrogen per oxide (H2O2) production". Br J Haematol, 95, 339-44.

ALZHEIMERS

Clements-Cortes, Amy; Ahonen, Heidi;  Evans, Michael; Freedman, Morris and Bartel , Lee. "Short-Term Effects of Rhythmic Sensory Stimulation in Alzheimer’s Disease: An Exploratory Pilot Study." Journal of Alzheimer’s Disease 52 (2016) 651–660. DOI 10.3233/JAD-160081. IOS Press. ISSN 1387-2877/16/$35.00 © 2016.

EYE, NEURONS AND BRAIN

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E. Duco Jansen."Optical Stimulation of Neural Tissue: Current State and Future Challenges." Department of Biomedical Engineering and Department of Neurological Surgery, Vanderbilt University, Nashville, TN. Medical Bionics Conference, Melbourne, November 23, 2011. duco.jansen@vanderbilt.edu.

Jagdeo, Jared R; Adams, Lauren E.; Brody, Neil I. and Siegel, Daniel M. ."Transcranial Red and Near Infrared Light Transmission in a Cadaveric Model." Red and Near Infared Light Transmission. PLOS ONE | www.plosone.org 1 October 2012 | Volume 7 | Issue 10 | e47460.

Medical Lasers/Neuroscience: "Photobiomodulation and the brain: Traumatic brain injury and beyond." http://www.bioopticsworld.com/articles/print/volume-9/issue-5/medical-lasers-neuroscience-photobiomodulation-and-the-brain-traumatic-brain-injury-and-beyond.html

Rojas, Julio C and Gonzalez-Lima, F. "Low-level light therapy of the eye and brain." Eye and Brain, 14 October 2011.

EXERCISE AND FITNESS

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Eduardo Foschini Miranda, PhD, Adriane Aver Vanin, MSc; Shaiane Silva Tomazoni, PhD, PT; Vanessa dos Santos Grandinetti, MSc;Paulo Roberto Vicente de Paiva, MSc; Caroline dos Santos Monteiro Machado; Kadma Kar ˆenina Damasceno Soares Monteiro, MSc; Heliodora Le˜ao Casalechi, PhD; Paulo de Tarso Camillo de Carvalho, PhD; Ernesto Cesar Pinto Leal-Junior, PhD. "Using Pre-Exercise Photobiomodulation Therapy Combining Super-Pulsed Lasers and Light-Emitting Diodes to Improve Performance in Progressive Cardiopulmonary Exercise Tests". Journal of Athletic Training 2016;51(2):129–135.

BACTERIA AND DISEASE

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Hamblin MR & Hasan T. (2004). "Photodynamic therapy: a new antimicrobial approach to infectious disease?" Photochem. Photobiol. Sci., 3, 436-450. 

Hamblin MR, O'Donnell DA, Murthy N, Rajagopalan K, Michaud N, Sherwood ME & Hasan T. (2002). "Polycationic photosensitizer conjugates: effects of chain length and Gram classification on the photodynamic inactivation of bacteria". J. Antimicrob. Chemother., 49, 941-951. 

BIOCHEMISTRY, LIGHT AND BODY

Akyol, Utkan Kamil, Ph.D., and Gu¨ngo¨rmu¨s¸ Metin , D.D.S., Ph.D."Effect of Biostimulation on Healing of Bone Defects in Diabetic Rats". Photomedicine and Laser Surgery, Volume 28, Number 3, 2010, Pp. 411–416, DOI: 10.1089=pho.2008.2478.

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Hamblin MR, Waynant RW, Anders J. (2006). "Mechanisms for low-light therapy I". Proc SPIE 6140

Hode, L."Penetration of light into living tissue."

Hoon Chung, Tianhong Dai, Sulbha K. Sharma, Ying-Ying Huang, James D. Carroll, and Michael R. Hamblin. "The Nuts and Bolts of Low-level Laser (Light) Therapy." Ann Biomed Eng. 2012 February ; 40(2): 516–533. doi:10.1007/s10439-011-0454-7.

Huang, Ying-Ying; Chen, Aaron C.-H.; Carroll, James D.; Hamblin, Michael R.. "Bi-Phasic Dose Response In Low Level Light Therapy." Dose-Response (Prepress)Formerly Nonlinearity in Biology, Toxicology, and Medicine Copyright © 2009 University of Massachusetts. ISSN: 1559-3258. DOI: 10.2203/dose-response.09-027. Hamblin.

Michael Hamblin and Praveen R Arany. "Low level laser (light) therapy and photobiomodulation: The path forward." Article · March 2015. DOI: 10.1117/12.2084049. https://www.researchgate.net/publication/281708244.

Samina T. Yousuf Azeemi and S. Mohsin Raza. "A Critical Analysis of Chromotherapy and Its Scientific Evolution." eCAM 2005;2(4)481–488.  doi:10.1093/ecam/neh137

PAIN REDUCTION AND INJURY

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Hu,Di ; Zhu, Shuyu and Potas, Jason Robert. "Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury." Hu et al. Journal of Neuroinflammation (2016) 13:200. DOI 10.1186/s12974-016-0679-3 . Journal of Neuroinflammation.

Jagan Nathan Vamanan PhD MSAR MAHMA PGA Acupuncture (Harvard). "Mechanisms Of Low Level Light Therapy in Acupuncture - Laser Acupuncture Laser Acupuncture in Treatment of Paralysis in Stroke; and Treatment of Carpal Tunnel Syndrome, Sports Injury, Post-op Pain, Wound Healing, Alopecia Areata."  drvaman@medaku.com www.medaku.com.

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Tiina Karu, PhD, DrSci."Is It Time to Consider Photobiomodulation As a Drug Equivalent?" Photomed Laser Surg. 2013 May; 31(5): 189–191. doi:10.1089/pho.2013.3510.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643261/

REPRODUCTIVE

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Yong-il Shin, Associate Professor, Pusan National University School of Korean Medicine ."Low-level Light Therapy for Primary Dysmenorrhea." https://clinicaltrials.gov/ct2/show/NCT02026206

ACNE

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Susan Pei, Arun C Inamador, Keshavmurthy A Adya, Maria M Tsoukas. "Light-based therapies in acne treatment." Indian Dermatology Online Journal REVIEW ARTICLE, Year : 2015; Volume:6; Issue:3; Page:145-157.

ANXIETY AND DEPRESSION

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Fredric Schiffer; Andrea L Johnston, Caitlin Ravichandran, Ann Polcari, Martin H Teicher, Robert H Webb and Michael R Hamblin."Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety." Behavioral and Brain Functions20095:46; DOI: 10.1186/1744-9081-5-46 ©  Schiffer et al; licensee BioMed Central Ltd. 2009, Published: 8 December 2009 https://behavioralandbrainfunctions.biomedcentral.com/articles/10.1186/1744-9081-5-46

"Transcranial Photobiomodulation For Depression: Near-Infrared Light & Laser Therapy." Mental Health Daily, Mental Health Blog. http://mentalhealthdaily.com/2016/07/25/transcranial-photobiomodulation-for-depression-near-infrared-light-laser-therapy/

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Hamblin, Michael. R; "Shining light on the head: Photobiomodulation for brain disorders." BBA Clin. 2016 Dec; 6: 113–124. Published online 2016 Oct 1. doi:  10.1016/j.bbacli.2016.09.002

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

Paolo Cassano ; Samuel R. Petrie ; Michael R. Hamblin ; Theodore A. Henderson  and  Dan V. Iosifescu. "Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis."  Neurophoton. 3(3), 031404 (Mar 04, 2016). doi:10.1117/1.NPh.3.3.031404; Accepted February 2, 2016 http://neurophotonics.spiedigitallibrary.org/article.aspx?articleid=2500206

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"Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression." https://clinicaltrials.gov/ct2/show/NCT00961454

Cassano P, Petrie SR, Hamblin MR, Henderson TA, Iosifescu DV. "Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis." Neurophotonics. 2016 Jul;3(3):031404. doi: 10.1117/1. NPh.3.3.031404. Epub 2016 Mar 4.

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Paolo Cassano ; Samuel R. Petrie ; Michael R. Hamblin ; Theodore A. Henderson ; Dan V. Iosifescu."Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis." Neurophoton. 3(3), 031404 (Mar 04, 2016). doi:10.1117/1.NPh.3.3.031404

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Julio C. Rojasa, b,F. Gonzalez-Limaa. " Neurological and psychological applications of transcranial lasers and LEDs."

BENEFITS OF PULSED LIGHT

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Javad T. Hashmi, MD, Ying-Ying Huang, MD, Sulbha K. Sharma, MSc, Divya Balachandran Kurup, MD, Luis De Taboada, MSEE, James D. Carroll, and Michael R. Hamblin, PhD. "Effect of Pulsing in Low-Level Light Therapy." Lasers Surg Med. 2010 August ; 42(6): 450–466. doi:10.1002/lsm.20950.

RELATED

Alaluf S, Muir-Howie H, Hu HL, Evans A & Green MR. (2000). "Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione". Differentiation, 66, 147-55. 

Hamblin MR & Mroz P. (2008). "Advances in photodynamic therapy: basic, translational and clinical." Artech House: Norwood, MA. 

Jan Tune´ r, DDS,1 and Peter A. Jenkins, MBA. "Parameter Reproducibility in Photobiomodulation". Photomedicine and Laser Surgery, Volume 34, Number 3, 2016, Mary Ann Liebert, Inc., Pp. 91–92, DOI: 10.1089/pho.2016.4105.

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"Photobiomodulation is making a name for itself."

http://www.litecure.com/medical/2016/02/photobiomodulation-therapy-is-making-a-name-for-itself/

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"How to Increase NAD+: The Molecule of Youth (and the danger of low NAD+)".

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This is an interesting website https://selfhacked.com/blog/my-review-of-lllt/